We are all conscious of the fact that slimming is actually a mega-dollar industry. With millions, or else millions of people spanning various ages struggling to lose weight, and very few pharmaceutically effective medications open to assist them, the desperate public will literally clutch at straws.
Per week sees the launch of the new “miracle” diet pill or potion along with a “surefire” diet sure to help believers shed kilos like magic.
Recently dr oz cambogia extract became the flavour of year. If you search the world wide web for facts about this exotic fruit extract you will certainly be assured that this is finally the miracle most of us have been expecting, that can produce dramatic weight reduction. Endorsements by various TV personalities and other luminaries have put into the allure of Garcinia cambogia slimming products.
According to a newly released local study in the Tshwane University of Technology (TUT) “this small fruit, reminiscent of a pumpkin in appearance, is now most popularly used and widely advertised as a weight-loss supplement”.
The comprehensive overview from TUT suggests that research has shown that “the extracts and also (-)-hydroxycitric acid (HCA), a main organic acid aspect of the fruit rind, exhibited anti-obesity activity”. Furthermore, it regulates the serotonin levels related to satiety, resulting in reduced diet.
“Based on clinical trial reports, Garcinia extracts were useful to obese individuals in many cases. In addition, studies on the toxicity and observations during clinical trials indicate that Garcinia is safe for use. Most of the negative reports have been associated with times when multi ingredient formulations were consumed along with the effect could stop being caused by a particular ingredient.”
The studies does, however, caution against a rise in serotonin, especially in individuals who take medicines that are already increasing serotonin levels, such as SSRIs. Research into these effects has not been conducted.
“Moreover, regulatory authorities must provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the study concluded.
Dr Ingrid van Heerden, an authorized dietitian, is of opinion that we ought to be cautious of does garcinia cambogia really work for weight loss, because it has not undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once someone that wants, or needs to shed weight, is hooked on the commitment of a slim, sexy figure, they may be sucked in to the deception. In case the drops, wafers or powders don’t work, well then it is the fault in the user who did not stick to one or some other often impossible instruction such as “stick to a 500 kcal/day diet” or “drink 5 litres water a day”, never that from the diet pill.
When eventually science and legislation meet up with the manufacturers, they calmly take product A off the market, change their formulation slightly, change the name to product B, then blithely sell product B using the same advertising gambits as before, raking in the money and pulling the wool over everyone’s eyes yet again.
In line with the ever-changing slimming product ranges, there are what one can call “ingredients of year” (sometimes an ingredient can last for only three to six months, however some have longer life spans, after which needless to say some are resurrected every 2 to 3 years).
We now have had apple cider vinegar (which has made many a comeback over the years), green leaf tea (which contains earned some merit in scientific research), hoodia (which just does not find a way to produce the research results that will make it a front-runner), willow bark (or salicylic acid which is good for aches and pains however, not as efficacious for slimming), and good old caffeine (with a diuretic effect thus assisting you shed weight before you replenish water within your body, as well as a stimulant effect when taken in big amounts that may be potentially dangerous), to list but several.
While it is perfectly entirely possible that more extensive and well controlled scientific studies will disclose an extract of Garcinia cambogia that contains a chemical called hydroxycitric acid (HCA) will assist fat loss, our company is at present not even sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage is required to achieve really significant weight loss.
Having Said That I hear you say: “For once we have a quantity of scientific studies that have been performed with Garcinia cambogia, so what’s the trouble?”
Well several of the studies failed to show any weight reduction differences between patients who took Garcinia pills and people who took dummy pills, while other studies did show differences in weight-loss using the subjects taking pills containing Garcinia losing a little more weight compared to those that failed to (Marquez et al, 2012).
A number of these weight loss differences were not really exciting either, and then we can’t say beyond doubt that Garcinia cambogia does promote weight reduction. Additionally, it seems likely that this may not be the wonder pill it is made to be.
Furthermore, most of the studies conducted up to now happen to be flawed (Critchley, 2013) . What it means is designed for example that in a study the control and experimental subjects were not well matched (i.e. they did not have exactly the same starting weight, age, portion of extra fat etc.), whilst in other studies too few subjects were used for the leads to be significant.
For that outcomes of studies to be plausible one has to compare “apples with apples” (i.e. well-matched subjects and controls) and you also need not just a few subjects to generate a similar result.
Around the positive side, we are able to state that there is certainly some evidence that Garcinia cambogia products may aid weight loss during a period of 12 weeks. No studies have been conducted for prolonged periods as yet (Marquez et al, 2012), which is viewed as a drawback.
There is also at the moment an argument concerning the safety of pills containing Garcinia cambogia – one selection of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez along with his coworkers (2012) claim that “at the doses usually administered, no differences have already been reported regarding side effects or adverse events (those studied) in humans between individuals given G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the usa has published a stern warning with regards to the hepatotoxicity of a diet product called “Hydroxycut”, which contains Garcinia cambogia. This writer collected case reports of patients who developed liver toxicity related to the previously discussed weight reduction product.
Evidently approximately a million units on this hydroxycitric acid product can be purchased a year in the united states. The patients who developed hepatotoxicity reported symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the number of hepatotoxicity cases reported were only a few, Lob indicates that monitoring of adverse events linked to dietary supplements such as these weight reduction products is woefully inadequate in the united states (as is the case in several other countries, including South Africa), together with the FDA only receiving about 1% of these negative reports.
Based on Lob (2009), the Poison Control Centres in the us are more likely to receive reports of adverse events associated with health supplements however are not equipped to coordinate such findings.
He cites the truly sobering demonstration of an item called “Metabolife 356″ which had been sold as a fat loss supplement in America. Lob’s states that the manufacturers received 14 000 reports over a period of five-years that documented “serious adverse events associated with their ephedra-containing product” which dexrpky17 cardiac arrest, strokes, convulsions and fatalities.
The makers failed to inform the FDA or any other US government authority of the reports. As astounding because this may appear, manufacturers of health supplements are certainly not expected to meet any of the specifications that happen to be strictly enforced when it comes to food and pharmaceutical products (medicines), for them to take advantage of this “ethical loophole” not to publish reports of negative and harmful events.
Eventually these events arrived at light and ephedra-containing products for slimming and also other uses were banned in the USA.
The implication contain in Lob’s warning is the fact that HCA or Garcinia cambogia extract can be potentially toxic unless sufficient, reliable evidence for the contrary is manufactured available.
At the present moment, we do not know enough about slimming products which contain warning garcinia cambogia to freely recommend its use. I tend to go along with Astell and coworkers (2013) who conducted a systematic report on double blind randomised controlled numerous studies to evaluate evidence seen on the efficacy of current nutritional supplements employed to control appetite or weight.
These authors figured that “According towards the finding from this systematic review, the evidence is not convincing in demonstrating that most nutritional supplements used as appetite suppressants for losing weight in the treatment of obesity are effective and safe.”
While we wait around for more extensive and conclusive evidence obtained with larger numbers of well-matched test subjects treated for extended periods with all the “gold standard” of double blind randomised controlled clinical studies, rather avoid using any weight-loss supplement that is not tested thoroughly.